More Complex than Previously Thought – Part VIII – DNA Differences

Previously, it was considered to be axiomatic that all cells in the human body contained the same DNA. However, recent research found differences between the DNA contained in blood cells and other tissue in the body.

This discovery may undercut the rationale behind numerous large-scale genetic studies conducted over the last 15 years, studies which were supposed to isolate the causes of scores of human diseases.

Except for cancer, samples of diseased tissue are difficult or even impossible to take from living patients. Thus, the vast majority of genetic samples used in large-scale studies come in the form of blood. However, if it turns out that blood and tissue cells do not match genetically, these ambitious and expensive genome-wide association studies may prove to have been essentially flawed from the outset.

This discovery sprang from an investigation into the underlying genetic causes of abdominal aortic aneurysms (AAA) led by Dr. Morris Schweitzer, Dr. Bruce Gottlieb, Dr. Lorraine Chalifour and colleagues at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal’s Jewish General Hospital. The researchers focused on BAK, a gene that controls cell death.

What they found surprised them. AAA is one of the rare vascular diseases where tissue samples are removed as part of patient therapy. When they compared them, the researchers discovered major differences between BAK genes in blood cells and tissue cells coming from the same individuals, with the suspected disease “trigger” residing only in the tissue. Moreover, the same differences were later evident in samples derived from healthy individuals.
“In multi-factorial diseases other than cancer, usually we can only look at the blood,” explained Gottlieb, a geneticist with McGill’s Centre for Translational Research in Cancer. “Traditionally when we have looked for genetic risk factors for, say, heart disease, we have assumed that the blood will tell us what’s happening in the tissue. It now seems this is simply not the case.”

It remains to be seen how many other differences will be discovered. But what is certain, is that a whole other layer of complexity has been added to the enormous complexity of biological systems. Yet we are told that there is “no evidence of design or a Designer.”

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